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Author Topic: Journal of Oncology Paper  (Read 3564 times)
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David Kent Warkentin
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« on: February 15, 2010, 03:07:43 PM »

International Journal of Oncology
February 2010 Volume 36 Number 2
 
Cytotoxic effects of ultra-diluted remedies on breast cancer cells

Authors: Moshe Frenkel, Bal Mukund Mishra, Subrata Sen, Peiying Yang, Alison Pawlus, Luis Vence, Aimee        Leblanc, Lorenzo Cohen, Pratip Banerji, Prasanta Banerji

Affiliations: Integrative Medicine Program-Unit 145, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA. frenkelm@netvision.net.il

Pages: 395-403

Abstract:
The use of ultra-diluted natural products in the management of disease and treatment of cancer has generated a lot of interest and controversy.

We conducted an in vitro study to determine if products prescribed by a clinic in India have any effect on breast cancer cell lines.

We studied four ultra-diluted remedies (Carcinosin, Phytolacca, Conium and Thuja) against two human breast adenocarcinoma cell lines (MCF-7 and MDA-MB-231) and a cell line derived from immortalized normal human mammary epithelial cells (HMLE).

The remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis.

These effects were accompanied by altered expression of the cell cycle regulatory proteins, including downregulation of phosphorylated Rb and upregulation of the CDK inhibitor p27, which were likely responsible for the cell cycle delay/arrest as well as induction of the apoptotic cascade that manifested in the activation of caspase 7 and cleavage of PARP in the treated cells.

The findings demonstrate biological activity of these natural products when presented at ultra-diluted doses. Further in-depth studies with additional cell lines and animal models are warranted to explore the clinical applicability of these agents.

http://www.ncbi.nlm.nih.gov/pubmed/20043074?itool=EntrezSystem2.PEntrez.Pubm
 
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David Kent Warkentin
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« Reply #1 on: February 16, 2010, 04:34:12 PM »

One of the authors, Moshe Frenkel, sent me the full article and here it is for you.  Pretty wonderful work.
He says
Quote
We did not mention homeopathy in the title or abstract, but it is well mentioned in the text, see the enclosed full article. This work was presented in the annual meeting of the Society of Integrative Medicine that was last  November in Columbia University in NYC. It was part of a whole session dedicated to homeopathy and cancer. Another review article on homeopathy and cancer is scheduled in ATHM this coming May.

* Cytotoxic_effects.pdf (835.85 KB - downloaded 445 times.)
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